The clock remained in the Anglesey family at Plas Newydd, now owned by the National Trust, until 2015.
It is priced at £19,500 by Ben Wright Clocks.
This Victorian gilt-brass month-going tripod clock by Thomas Cole is engraved with a dedication dated July 6, 1861, from the Marchioness of Anglesey as a birthday present to her husband, the 2nd Marquess of Anglesey.
The clock remained in the Anglesey family at Plas Newydd, now owned by the National Trust, until 2015.
It is priced at £19,500 by Ben Wright Clocks.